Endocrine Abstracts

The combination of hypophosphataemia and hypercalcaemia has numerous aetiologies, which can be challenging in the clinical setting. Careful early biochemical identification will facilitate appropriate further imaging and management. We report a case of a gentleman who presented in his ninth decade with deteriorating cognition, proximal muscle weakness and reduced mobility on a background of hypertension, type 2 diabetes with associated ...

Background: The British Thyroid Association’s thyroid cancer guidelines (2014) advocate the U1-5 nodule grading system as a primary diagnostic and classification tool.Aims: We assessed whether practice reflected guidelines, and examined patient outcomes.Methods: Patients with a thyroid ultrasound, undertaken by radiographers or general radiologists, in January-June 2015 were identified. Investigation and outcomes...

Introduction: Ectopic ACTH syndrome is rare but is frequently severe condition because of the intensity of the hypercortisolism that may be dissociated from the tumoral condition. It should often be considered as an endocrine emergency requiring an emergency response both in terms of diagnostic procedures and therapeutic interventions. Patient management is complex and necessitates dual skills, in the diagnosis and treatment (1). Etomidate, an imidazole-derivative anesthetic a...

Sarcoidosis is a granulomatous multi-systemdisorder of unknown ethology. It has a higher prevalence in Northern Europe and the UK. Neurosarcoidosis is a relatively less common, but serious complication of sarcoidosis. CASE: A 48 year old man presented to the hospital with intermittent fever, and neck pain and stiffness, of six weeksduration. This was associated with excessive tiredness, loss of libido, decreased appetite, and unintentional weight loss of two stone over a perio...

Background: Adipose tissue exhibits an altered adipokine secretion profile in obesity which is pro-inflammatory and relates to higher risk of cardio-metabolic diseases. Asprosin is a novel pleiotropic adipokine with orexigenic and glucogenic effects which is secreted in response to fasting. Elevated circulating asprosin levels have been shown in obesity and type 2 diabetes, as well as in other cardio-metabolic diseases. Furthermore, in vitro studies have reported pro-...

Background: Newer biological drugs such as immune checkpoint inhibitors (ICI) have recently revolutionized cancer therapy. However, hypophysitis and adrenalitis are recognized side-effects of these new therapies. Hypothalamus pituitary adrenal (HPA) axis dysfunction is associated with serious morbidity and mortality. This study aimed to monitor whether the ICI related HPA axis dysfunction recovers.Materials and Methods: We have conducted a retrospective ...

Background: Neuroendocrine tumor (NET) metastases to the heart are found in 1-4% of NET patients and have been reported primarily in the form of individual cases. We investigated the incidence, clinical characteristics, imaging features, and outcomes of NET patients with cardiac metastases on 68Ga-DOTATATE PET/CT.Methods: The medical records of 406 neuroendocrine tumor patients who underwent 68Ga-DOTATATE PET/CT for their clinical c...

Dopamine agonists can falsely elevate plasma and urinary metanephrines, thus making the diagnosis of pheochromocytomas in patients taking these medications challenging. We present the case of an 80-year-old female care home resident with a background of hypertension, Parkinson’s disease (PD), dementia and pernicious anaemia. She presented with weight loss, unilateral leg swelling and abdominal distension. A computed tomography (CT) showed a 5.6 cm heterogeneously enhancin...

A 28-year-old female presented to ED with one week history of flu-like symptoms, palpitations, increasing breathlessness, and productive cough with copious sputum, of two days duration. There was h/o some weight loss over the last year, with episodic palpitations over the last 8-10 years that increased in frequency over the last one year. She had a family history of hyperthyroidism paternally and maternally. On examination, there was mild lid-lag and proptosis. She was tachypn...

A 57-year-old woman was referred in 2012 following an incidental finding of a pituitary macroadenoma. It measured 17×9 mm and was confined to the sella. There was no clinical or biochemical evidence of pituitary dysfunction. In 2017, she was found to have proximal myopathy, plethoric facies and purple abdominal striae. She was also on medication for hypertension and type 2 diabetes. There was no history of sleep apnoea, fractures or use of exogenous steroids. An MRI showe...